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Symptoms include a headache, dizziness, or fainting when standing. Always buy your ED medications from a reputable supplier as there are a lot of counterfeit products on the market. It works within 30 to 60 minutes, but may be taken up to four hours before sexual activity. Sildenafil blocks the action of an enzyme known as cGMP-specific phosphodiesterase type-5 (PDE-5). Taking Viagra could help prevent the problem and avoid an injury with lifelong consequences, he says. Combining the treatments has a cumulative effect — penile injection therapy makes your erections hard, and adding Viagra makes them harder and even more long-lasting.

It is eliminated predominantly by hepatic metabolism and is converted to an active metabolite with properties similar to the parent, sildenafil. Both sildenafil and the metabolite have terminal half lives of about 4 hours. There was no effect on sperm motility or morphology after single 100 mg oral doses of VIAGRA in healthy volunteers. Single oral doses of sildenafil up to 100 mg produced no clinically relevant changes in the ECGs of normal male volunteers. PDE5 inhibitors, including VIAGRA, may potentiate the hypotensive effects of GC stimulators. Hypersensitivity reactions have been reported, including rash and urticaria .

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If you are taking sildenafil to treat erectile dysfunction, follow your doctor’s directions and the guidelines in this paragraph. The best time to take sildenafil is about 1 hour before sexual activity, but you can take the medication any time from 4 hours to 30 minutes before sexual activity. If you have certain health conditions or are taking certain medications, your doctor may tell you to take sildenafil less often. However, if you take sildenafil with a high-fat meal, it will take longer for the medication to start to work. Viagra is an extremely costly drug, and in many ways, it defies traditional logic about the prices of prescription drugs. The price of Viagra rose 190 percent between 2012 and 2017, while the price of Cialis rose 187 percent; these represented the largest price increases of any prescription medications. When sildenafil was released as the generic Viagra in 2017, it didn’t carry with it all of the perks that normally make generic medications less expensive.

Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. You should be able to achieve an erection between one and four hours after taking Viagra. if you take other medicines to treat pulmonary arterial hypertension, such as riociguat .

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VIAGRA has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers.

  • Rarely, sudden decreased vision, including permanent blindness, in one or both eyes may occur.
  • Keep your diabetes under control, and you can lower your risk of sexual and urologic problems.
  • “It should not be given to patients who may take nitroglycerin,” he points out.
  • Get medical help right away, if you have any of the symptoms listed above.

Your personal mileage may vary, depending on your age, overall health, other medications, and dosage taken. Viagra , Cialis , Levitra , and Stendra are all part of a family of drugs called PDE-5 inhibitors. PDE-5 (phosphodiesterase type-5) is an enzyme that breaks down a molecule called cGMP, resulting in vasoconstriction, or the narrowing of blood vessels. The Food and Drug Administration approved Viagra in 1998, and by the end of 2005, more than 27 million men worldwide had been prescribed sildenafil for the treatment of ED . If you have any medical questions or concerns, please talk to your healthcare provider.

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Sildenafil belongs to a group of medicines called phosphodiesterase 5 inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. Viagra can help you have an erection when sexual stimulation occurs. It is not known whether this medicine will harm an unborn baby.

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